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Quicksilver... Oops
I am growing to love Quicksilver, which seems to be a religion among some Mac users. I've not yet reached disciple status, but I am finding it very handy. If I could make it search my mail, I would probably never open Spotlight.
That being said, I've only used it for a week or so, and while trying to figure out how exactly I could search through my mail, I accidentally used the "Open All Unread Mail" option. To say the least, hilarity ensued.

