We're back from Boston DrupalCon 2008 and busy catching up with everything else. The site that I'm using this technique on will launch soon, but I wanted to share it now. Also, check out my Technorati Profile!
Drupal's Image module provides you with a pretty no-frills image gallery out of the box. In a site I was recently building, I wanted to present large imagery, but my main content column inside the site was somewhat cramped, and so I decided that some sort of Lightbox / Thickbox effect was in order to present the images to the user.
Luckily, with two extra modules and changing a single line of template.php code, you can get your gallery up and running with Lightbox.